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Chunk #6 — Results — Identifying Context-Specific Local Genetic Regulatory Variants

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Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.
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For a minority of eQTL, associations were observed across conditions, but with the direction of effect switching between those conditions. We mapped the most significant association per condition (17) and identified 20 genes, including HIP1 and STEAP4, with shared peak eQTLs mapping to a single locus but with opposing directions across conditions (Fig. 1C, fig. S6, and table S2).