Chunk #41 — Methods — Statistical methods. — Deming regression of EUR τ* on EAS τ*.

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Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.

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We used an iterative pruning approach to identify independent IMPACT annotations. For each trait, we ranked all 707 IMPACT annotations by their τ* significance values. Then, we selected the lead annotation, removed all annotations correlated with Pearson r > 0.5 and selected the next lead annotation, and so on. For each trait, we regressed the EUR τ* on the EAS τ* using Deming regression, to account for standard errors, with the R function deming from the package deming. We tested the null hypothesis that the slope is equal to 1.