The other predominant model of studying GxE interaction is via studies that measure specific genotypes. The most well known literatures for specific GxE interactions involve the interaction between the MAOA genotype and childhood abuse in the development of antisocial behavior (Caspi et al., 2002), and the interaction between a polymorphism in the serotonin transporter gene and stressful life events in the development of depression (Caspi et al., 2003). Subsequent to the initial high-profile publications, there has been a literal explosion of measured GxE interaction studies. These literatures have been highly controversial, full of high-profile replications (Kim-Cohen et al., 2006), failures to replicate (Risch et al., 2009), and thoughtful commentaries on the replications and nonreplications that have been observed (Caspi et al., 2010).
