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Chunk #25 — Comment

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Familial influences on conduct disorder reflect 2 genetic factors and 1 shared environmental factor.
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We also evaluated the association of these 3 familial factors with relevant measures of personality, psychopathology, and demography. For many outcome variables examined, the magnitudes of the associations differed meaningfully for the 3 factor scores. The finding of robust relations for the rule-breaking factor with traits of novelty seeking and neuroticism suggests that this component of CD relates most closely to the disinhibitory-externalizing dimension of psychopathology identified in the child and adult clinical literatures.13,29,30 Also consistent with this interpretation are the robust positive relations of this factor with anxious-dysthymic (internalizing) tendencies in the form of GAD and alcohol dependence and its moderate negative relationship with educational attainment. By contrast, the more selective association of the overt aggression factor with the broad trait of neuroticism (encompassing hostility and mistrust, as well as anxiousness) and its lesser relationship with the narrower GAD variable (reflecting general anxiousness and dysphoria), coupled with its strong association with adult antisocial personality disorder symptoms, appears consistent with a more callous-antagonistic disposition, perhaps indicative of the “meanness” facet of psychopathy.12,31,32 Finally, a 3-factor exploratory phenotypic factor analysis exhibited