in the brain and is an important functional element in dopaminergic, cholinergic, GABAergic and glutamatergic synapses, and hence the regulation of neuronal excitability (Saenz del Burgo et al., 2008). The advantage of a family-based study design is robustness against population substructure and the availability of the genotypes of both parents, which enables a more correct evaluation of genotype errors (cf. Kang et al., 2012). Following up this finding, a recent study from our group examined the effects of KCNJ6 SNPs on developmental trajectories of the same theta ERO phenotypes in auditory and visual oddball tasks in adolescent and young adults (12–25) from the COGA prospective study; significant age- and gender-specific effects were found, with some effects of scalp locality and task modality (Chorlian et al., in press).
