Chunk #24 — RESULTS — Polygenic architecture and co-morbidity rates for recurrency

Source

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.

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In summary, compared to individuals with single-episode depression, those with recurrent depression showed significantly increased polygenic load particularly for depression, anxiety, bipolar disorder and neuroticism-PRS as well as higher rates of comorbid psychiatric disorders.