an adaptive response that could potentially promote fear extinction when a threat is no longer imminent and, speculatively, a decreased reliance on substances for affect regulation. In support of this hypothesis, a post-hoc SEM demonstrated that the pathway from CSA to cannabis dependence symptoms was partially mediated by using cannabis to control one's mood in GG individuals only. Notably, however, this interpretation remains speculative and must be tempered by our inability to temporally disentangle using marijuana to change one's mood from cannabis dependence symptoms.
