We additionally obtained genotype data on a sample (488 cases 540 controls) collected by the Pittsburgh group, details of which are given in reference (22). The group from Dublin (Corvin and colleagues) provided genotypes based upon a Taqman assay for an extra set of 352 Irish cases and 178 Irish controls that had not been included in fatSNP2. The diagnostic and ascertainment practices were as for the part of their sample described in reference (4).