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Chunk #18 — Methods — Functional Connectivity Analysis

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Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy.
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A novel index of physiological lagged connectivity, namely lagged phase synchronization was used as measure of functional connectivity between any pair of BAs [30]–[32]. Lagged phase synchronization measures the similarity (a corrected phase synchrony value) between signals in the frequency domain based on normalized (unit module) Fourier transforms; thus it is related to nonlinear functional connectivity. This lagged connectivity measure is accurately corrected as it represents the connectivity between two signals after the instantaneous zero-lag contribution has been excluded. Such a correction is necessary when using scalp EEG signals or estimated intracranial signals (EEG tomography) because zero-lag connectivity in a given frequency band is often due to non-physiological effects or intrinsic physics artifacts, in particular volume conduction and low spatial resolution that usually affect other connectivity indices [26], [27]. Thus, this measure is thought to contain only physiological connectivity information.