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Chunk #34 — Study Design: Candidate Gene? GWAS? Sequencing?

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Incorporating genetics into your studies: a guide for social scientists.
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reasonable and cost-efficient to genotype a GWAS chip, even if a more targeted candidate gene strategy is proposed. Currently, GWAS chips cost approximately $200 to purchase and $100 to process, which may still make them out of reach for many social science projects where genotyping is not the primary focus. However, as costs continue to drop, the cost-benefit ratio may shift in favor of running GWAS chips. There are also custom chips available, which may provide an interim compromise of genotyping on a larger scale and covering far more candidate genes in a more cost-efficient manner than genotyping only a few candidates. But this still requires the selection of candidate genes, and does not have the advantage of genotyping across the genome for future collaborative purposes.