We next examined rG between different definitions of MDD and comorbid diseases, using cross-trait LD score regression (LDSC)43 to estimate rG with neuroticism and smoking (Extended Data Fig. 3 and Supplementary Tables 16 and 17) in the UK Biobank, as well as with all psychiatric conditions in the Psychiatric Genomics Consortium (PGC)44, including PGC1-MDD39, and depression defined in 23andMe4 (Supplementary Table 1). Figure 4a and Supplementary Table 18 show few differences in rG estimates between other psychiatric disorders and the different definitions of MDD in the UK Biobank, consistent with previous reports45.
