Using the standard Benjamini-Hochberg procedure for FDR, at an expected proportion of 10% of false positives, we identified the following four systems as potential contributors to genetic risk for AD: norepinephrine, glutamate, GABA, and CRH. The 27 SNPs in these systems together accounted for 6.8 % of the total phenotype variance, although this is likely an overestimate due to selection bias.
