Chunk #11 — RESULTS — FLOW-CYTOMETRIC AND MOLECULAR ANALYSES

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B-cell clones as early markers for chronic lymphocytic leukemia.

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As a second step, for all prediagnostic blood samples, analysis of IGHV gene rearrangement was performed by RT-PCR assay. A monoclonal band was demonstrated in 43 of 45 patients (96%) (Fig. 2). Patients 6 and 8 showed no evidence of monoclonality (Table 2).