and expression of the linked gene. Although links were enriched in close proximity to the gene TSS, we also observed a substantial number of long-range putative regulatory relationships, with 58% of links spanning a distance of >100 kb from the gene TSS (Fig. 2j). Linked genes were on average linked to ~six peaks (mean = 6.37, s.d. = 7.09), whereas linked peaks were linked to ~one gene on average (mean = 1.57, s.d. = 1.26) (Fig. 2k).
