total heritability of the first two bins (MAF < 0.1) was similar across studies, 2.6% for our study versus 4% for Davis, estimates for specific bins were not similar; in the Davis et al. study, the MAF bin from 0.01–0.05 accounted for essentially no heritability (0.0001%) whereas our estimate was much larger (2.6%) (Figure 1; Table S9). A portion of the difference could be due to the number and nature of the SNPs falling in this bin: there were approximately ten times more genotyped SNPs falling into this bin in the current study compared with Davis et al. (Table S9); however, Davis also imputed genotypes for over 2 million SNPs for this bin and those genotypes did not alter their heritability estimate in that bin (see their Table 2).
