We also examined polygenic effects on the organizational properties of network nodes. Externalizing PS predicted higher Participation Coefficient for left amygdala (p < .001 [corrected p = .004]), right amygdala (p = .002 [p = .012]), and left rostral ACC (p = .012 [p = .039]), suggesting that genetic variation related to externalizing modulates the importance of these nodes for communication between functional modules in the global network. The externalizing PS also nominally predicted higher Within-Module Degree Z-score Coefficient for right pallidum, suggesting externalizing polygenic variation modulates the importance of this node for communication within its functional module, but this did not survive correction for multiple comparisons (p = .046 [corrected p = .460]). These findings suggest that genetic variation related to externalizing modulated the extent to which these nodes functioned as communication hubs between functional modules.
