The 39 LD-independent index SNPs with p<1×10−5 were investigated for replication in the deCODE sample (706 cases, 6,068 controls). None of the individual SNPs were replicated after Bonferroni correction (replication threshold for 39 tests, p<0.0013; Table 1; Table S4); 23 of 39 putative Tourette syndrome risk alleles had the same direction of effect, though this was not statistically significant (Binomial two-way sign test, p=0.34).
