The results reported here represent some level of replication for other genes as well: CDH13 and VGLL4 have been implicated previously in GWAS analyses for alcohol dependence (Johnson et al., 2006; Treutlein et al., 2009a) and major depression (Muglia et al., 2008), respectively. Seven genes implicated in the current report – CTNNA2, ESRRG, FBXO21, GALNT2, GRID1, IGSF21, and SMARCA2 – were reported previously to be proximal (within 250kb) and in reasonably high LD (r2≥0.5) with markers associated with major depression (Sullivan et al., 2009). AGTR1, CSMD2, and NMUR2 were nominally associated with alcohol dependence (via “clustered positive SNPs”) in a report by Johnson and colleagues (2006).
