Similar HFO between 200 and 300 Hz have been found in Parkinson’s disease patients with DBS electrodes implanted in the internal part of the globus pallidus (GPi) (Tsiokos et al., 2013). Like HFO in the STN (Foffani et al., 2003, López-Azcárate et al., 2010, Litvak et al., 2012, Tan et al., 2013), the amplitude of this activity increases during movement. Also, Connolly et al. (2015) showed that PAC between HFO and beta oscillations in the GP emerges when rhesus macaque monkeys are rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injections. PAC gradually increased with higher MPTP dosages, which were accompanied by more severe parkinsonian states.
