GEUVADIS LCLs. For GTEx tissues, the prediction R2 values are 0.0367 (adipose), 0.0358 (tibial artery), 0.0356 (left ventricular heart), 0.0359 (lung), 0.0269 (muscle), 0.0422 (tibial nerve), 0.0374 (sun exposed skin), 0.0398 (thyroid), and 0.0458 (whole blood). Interestingly, we also find a substantial departure from the null distribution of expected R2 values for predicted expression using DGN weights in each of the nine GTEx tissues suggesting that models developed in whole blood are still useful for understanding diseases that affect other primary tissues (Supplemental Figure 3). Consistent with this, average prediction R2 is highest for whole blood as expected but the loss in power for other tissues is modest.
