There are several reasons for the enhanced discovery in our study: an increased sample size, multiple BP measures (reducing phenotype variability), better designed arrays with increased genomic coverage40,41, and larger imputation reference panels (reducing error and providing additional imputed SNPs). We showed a 25% SNP effect se reduction using multiple BP measurements. In addition, 15 SNPs not present in 1000 Genomes were genome-wide significant in the UKB data alone (6.2% of the 241 novel SNPs), while none of the SNPs in 1000 Genomes surrounding them met genome-wide significance.
