We evaluated evidence for preferential brain and brain regional expression patterns of the 104 genes identified in Table 2. Brain libraries contained at least two expressed sequence tags (ESTs) that corresponded to 79% (82/104) of the genes in Table 2. These ESTs came from amygdala (255), adult brain (736), developing brain (1243), caudate (striatum) (63), cerebellum (375), cerebral cortex (52), hippocampus (554), hypothalamus (274), medulla oblongata (31), substantia nigra (43), subthalamic nucleus (38), thalamus (187), corpus callosum or other white matter (72) and peripheral nerve (97). Levels of expression for this set of genes (compared to all genes) displayed nominal significance in thalamus, hippocampus, amygdala, cerebellum, substantia nigra, hypothalamus and whole brain (p = 0.002, 0.003, 0.004, 0.005, 0.02, 0.03 and 0.02, respectively). After Bonferroni corrections, values for thalamus and hippocampus (p = 0.032 and 0.045, respectively) retained significance. Assessments of the “more reliable” subset of ESTs revealed significant over expression in hippocampus and whole brain (corrected p ca 0.01 for each).
