The combination of deep phenotyping and full genome sequencing makes it possible to reverse the polarity of genome-wide analysis and to measure the impact of defined sequence variants at many levels to biological organization—from mRNAs to metagenomic profiles and behavioural variation. The combination of experimentally tractable murine resources, such as the BXD family, with human clinical cohorts such as BioVU, is an efficient and scalable way to validate and translate genes to the linked sets of phenotypes. Even negative results can be genuinely informative, essentially an inverse of missing heritability.
