Inconsistent associations have been reported between variants in the cannabinoid receptor 1 gene (CNR1), to which cannabinoids putatively bind, and the fatty acid amide hydrolase gene (FAAH) and cannabis dependence symptoms (see Agrawal and Lynskey46 for a review). As with alcoholism, GABRA2 (encoding the α2 subunit of the GABA (gamma-amino-butyric acid) receptor) has been examined for cannabis dependence but with limited success.39, 47, 48
