Expression probes were mapped to the cDNA sequence from Ensembl v45_36g [23] and the NCBI build 36 genome assembly if necessary. Probes that had less than 96% sequence homology or that mapped to multiple loci were removed. Subsequent analyses were confined to autosomal probes, in order to prevent sex specific effects on gene expression. After removal of probes that map to sex chromosomes, data was quantile-quantile normalized [24].
