Kendler et al. (2011) conducted a pathway enrichment analysis using ALIGATOR (Holmans et al., 2009) to test whether specific gene-sets defined by Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG), corresponding to specific categories and pathways, were enriched for association with AD in their GWAS sample. They found a significant enrichment in both AAs and EAs, with 62 and 96 significantly enriched categories/pathways at P≤0.01, respectively, including those involving lipid and cholesterol metabolism and cell adhesion, the latter having been previously associated with several addiction-related phenotypes (Gelernter et al., 2006; Gelernter et al., 2014b; Hart et al., 2012; Johnson et al., 2006; Yang et al., 2007; Yang et al., 2008).
