Other studies have suggested a link between the genetic influence on various forms of impulsivity and drug abuse. Trait impulsivity, i.e., high premature responding, was associated with low D2/3 receptor availability and later cocaine self-administration (Dalley et al., 2007). In another study, rats selectively bred for high saccharin intake, a correlated trait to alcoholism, were more impulsive in a DD task than low saccharin drinking rats (Perry et al., 2007). Alcohol-preferring Lewis rats, which show conditioned place preference to cocaine (Kosten et al., 1994) and reduced conditioned taste aversion to alcohol (Roma et al., 2006) also showed differences in autoshaping that suggest higher impulsivity (Kearns et al., 2006).
