To better understand comorbidities across the lifespan, we used two age related variables, AAA and AOO, in moderator analysis by meta-regression. An increasing AAA was associated with an increase in prevalence of MDD, panic disorder and SUDs, and a decrease in prevalence of GAD and psychosis. An increase in AOO was associated with an increase in prevalence of personality disorders and a decrease in prevalence of GAD, PTSD, BDD, ODD, and agoraphobia. These trends are clinically informative in guiding inquiry for comorbidities.
