1. We observed a substantial deviation from the null distribution, indicating that exon inclusion of a large proportion of skipped exon events in the DLPFC transcriptome can be partially explained by the genetic variants. We used a Bonferroni p cutoff = (1/6284) × 0.05 = 7.96 × 10−6 for the significance of cis-regulation because our subsequent Mendelian randomization requires strong dependency of splicing outcome on genetic variants. This resulted in 1093 SE events.
