Conditional analyses of the 19q13.2 locus revealed three independent genome-wide significant signals tagged by rs56113850, rs113288603, and esv2663194 (Fig 3 and Table 2). The same independent SNPs emerged in all the three cohorts. A fourth independent signal (rs12461964) emerged in the conditional analysis of the FINRISK2007 sample; however, this was not seen in the meta-analysis of the three samples. All the independent SNPs are imputed, and are located either within CYP2A6 or at most at a distance of 8 kb from the gene. For all the independent SNPs the minor allele decreases NMR, i.e. decreases nicotine clearance rate (Table 2). None of the independent SNPs have predicted functional effects.
