report), chronic-intermittent phencyclidine treatment in adolescent rats (Vigano et al., 2009), and exposure to repeated restraint stress in adolescent mice (Patel et al., 2005) all increased 2-AG, but not anandamide, in the prefrontal cortex (see also Seillier et al., 2009). Generalizations across models may provide important information about the role of the endocannabinoid system in response to chronic stressors (Hohmann et al., 2005, Rademacher et al., 2008, Rossi et al., 2008).
