Here, we leverage GWAS summary statistics generated by large datasets from the Psychiatric Genomics Consortium (PGC) and the UK Biobank to estimate genetic correlations between MD, AD, and two measures of AC (AC-quantity, AC-frequency) via linkage disequilibrium (LD) score regression (Bulik-Sullivan et al., 2015a, 2015b). Further, we investigated support for causal mechanisms linking these psychiatric disorders and AC via two-sample MR analyses, which use genetic variants to assess whether an exposure has a causal effect on an outcome in a non-experimental setting (Burgess et al., 2015).
