We addressed the question of whether those functions which are significantly differentiated in one population inform differentiation in a closely-related population (i.e., differentiation of function may be shared by closely-related populations). For example, differentiation might be similar for each of CHB and JPT when individually compared to all the other six populations (or for LWK and MKK and YRI). To address this, we assessed the enrichment in the p-value distribution for GO terms predicted in one population to be significant in another population (for each comparison both populations being compared are excluded). For example, we identify the GO terms that are significantly differentiated between CHB and all other populations (excluding JPT) and compare their p-values to the p-value distribution for terms with JPT and all other populations (excluding CHB).
