(−) chronological age. Alz, on the other hand, is the highest in chronologically older patients and does not correlate with BioAge. Thus, patients with high NdStress likely have more accelerated aging trajectories than patients with high Alz. The older chronological age of Alz onset may suggest that the acceleration of BioAge due to Alz does not occur until the level of BioAge of the brain reaches a certain threshold. The quantitative assessment of the brain biological age in terms of BioAge and the rate of its disease-related acceleration in terms of NdStress are two critical hypotheses proposed in this work.
