A more complex challenge can be the process of matching community priorities with the scientific interest and expertise available within the network structure. In our experience, it has been helpful to set a sufficient number of priorities and for those priorities to be broadly enough phrased (e.g., “problem alcohol use”; “cancer prevention”) to allow a breadth of research questions to fall within the scope of those priorities. Creating partnerships with external content experts can help a PBRN to address those priorities outside its existing expertise.