Chunk #12 — Methods — Sedative and Ataxic Effects of Acute Administration — Loss of righting reflex

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Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration.

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To assess the sedative effects of ethanol, WT and KO mice (n = 12) were injected with 3.5 g/kg ethanol. At intervals of one minute, mice were tested for their ability to recover an upright posture within 10 seconds. The time of loss of righting reflex and duration of loss were recorded.