Table 1 displays additional descriptive information on the nine candidate SNPs, including location within the gene, as derived from estimates of chromosomal position within the dbSNP database, and sample-specific frequencies for the two nucleotide bases comprising each SNP [adenine (A), cytosine (C), guanine (G), thymine (T)]. All allele frequencies were in line with those reported in the European American sample of the HapMap project (as displayed in the dbSNP database, build 36.3). Moreover, all SNPs were in Hardy Weinberg equilibrium, indicating that the allele frequencies observed in the European American subset of the CDP sample reflect the population frequencies that would be expected within a randomly mating population, providing further support for the absence of potential genotyping problems. To assess the influence of CHRM2 within our analyses (described below), each of the SNPs is coded 0, 1, or 2, reflecting an additive genotypic model. This coding is in reference to the number of copies of the minor (least frequently observed) allele for all SNPs, which, in this sample, also correspond to the allelic variants associated with increased risk.
