of discernible difference between h2SNP and rG estimates between depression subtypes suggests that the best approach, currently, is to maximize the sample size in order to reduce sampling error and obtain more accurate point estimates. However, addressing recurrence, sex and ancestral heterogeneity in a large ascertained cohort does have intrinsic merit, as demonstrated previously by CONVERGE6, with the implication that addressing several sources of heterogeneity has more utility than implementing recurrence and sex separately6.
