Chunk #12 — Results — Comparison of Biophysical Parameters of Sensory Neurons from 118AA and 118GG Mice

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Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons.

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In the first set of experiments, the biophysical parameters of TG neurons isolated from 118AA and 118GG mice were compared. Figure 1A shows the neuron capacitance, a measure of cell size, between both 118AA and 118GG group of neurons. The results show that the two groups were nearly identical (two-tailed, unpaired t test, P = 0.92). Further, Figure 1B shows the Ca2+ current density of both neuron sets. The statistical comparison of this parameter showed that there were no significant differences between both groups (two-tailed, unpaired t test, P = 0.32).