Our results should be interpreted with caution based on the limitation of a relatively small size and the possible confounding effect of antipsychotic medication. However, a small sample is not uncommon in neuroimaging research on SLPE, which is thought to be the direct result of the difficulty in recruiting patients with SLPE and single brain pathology owing to the rarity of the disorder. Nevertheless, we matched the patient groups for age and epilepsy characteristics, and those with low IQ and gross organic lesions were not included. Most patients in the psychotic group were taking low dose of antipsychotics (mean chlorpromazine equivalent dose of 203.7±308.4 mg/day). However, there was no significant correlation between chlorpromazine equivalent dose and connectivity measures, suggesting that pharmacological agents may not influence our results. Another potential limitation is that our ROI-based connectivity analysis relied on cytoarchitectonically-defined regions (i.e., BAs) that are projected onto the Talairach atlas and show interindividual variablity due to differences in brain size, shape, etc [76], [77]. Although using a BA-approach to explore the convergence of brain function and structure is a common practice
