be linked to alcohol-related phenotypes (Bierut et al 2002; Nurnberger et al 2002). In addition, increased allele sharing was seen near two markers called D1S1648 and D1S1588 between 100 and 110 centi-Morgan (Nurnberger et al 2002). The same portion of chromosome 1 that exhibited linkage with the AorD phenotype also showed suggestive linkage with the ALC phenotype alone (Reich et al 1998). This suggests that a gene or genes on chromosome 1 may predispose some people to depression and others to alcoholism.
