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Chunk #40 — Discussion — IQ-related differences

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Topological organization of functional brain networks in healthy children: differences in relation to age, sex, and intelligence.
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Previous studies of fMRI on working memory tasks [92], verbal and non-verbal reasoning tasks [93], [94], [95], and at rest [96] have indicated that the functional interactions between multiple brain regions are strongly related to the neural basis of intelligence. In this study, we investigated the correlation between IQ and the topological properties of functional brain networks. We found no IQ-related change in the global network properties. However, recent studies showed that intelligence is highly correlated with both the global and local efficiencies of structural and functional brain networks [15], [16], [91]. Several factors might contribute to the discrepancies between the present study and previous studies. First, the subjects included in this study were healthy children, whereas the previous studies all involved adults. The IQ-related differences in the network properties would be affected by the developmental trajectories of the functional connectivity between sexes [97]. Therefore, separating age- and sex-specific groups to investigate the correlation between brain network properties and intelligence would be useful. Second, although the similar parcellation of the whole brain used in this study and the previous studies