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Chunk #15 — Materials and Methods — Data analysis — Classification of NAc Cell Firing

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Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell.
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of each cell type into type PR, type RFe, type RFi or type NP cells was determined with z-score statistics for each neuron (p < 0.05). Z-scores were calculated as (x + b)/s, where x is the mean firing rate during the 1 s period of peak or trough firing relative to the response, b is the mean firing rate during the baseline period, and s is the standard deviation of the baseline period. Baseline consists of firing during the −10 to −7.5 s preceding the reinforced response for each cell. Signal-to-baseline (S:B) ratios for phasic cell firing were determined by dividing the mean firing rate during the 1 s period of peak or trough firing relative to the response (i.e., the signal) by the mean firing rate during the baseline period.