Additionally, one module with striking anatomical specificity for the paraventricular thalamus and central glial substance (asterisks in M5 eigengene histogram, Fig. 3c) corresponded to expression in the ventricular ependymal lining and choroid plexus. One highly regionalized neuron-related module (M6) was enriched in the striatum (the dopamine receptorDRD1 in Fig. 2a is a hub gene). Thus, a major feature of the adult brain transcriptome profiled in this manner is the degree to which anatomical variation reflects the cellular make-up of different brain regions, both neuronal and non-neuronal.
