(Burke and Barnes, 2006; Yankner et al., 2008). Interestingly, transcriptional profiling of different tissues has revealed similar age-related changes across different tissues, including genes involved in stress response, inflammation, and Ca2+ homeostasis, whereas tissue-specific changes of the aging human cortex were detected in genes controlling synaptic functions (Adler et al., 2007; Fraser et al., 2005; Lu et al., 2004; Murphy, 2006).
