connections in some individuals with ASD. However, a gain-of-function mutation in NLGN3 (R451C) found in ASD confers an increase in GABAergic synaptic signaling (Etherton et al., 2011; Pizzarelli and Cherubini, 2013; Tabuchi et al., 2007). These apparently discrepant results may be reconciled by the suggestion that the balance, rather than absolute numbers, of glutamate and GABA neurons is important for function. Comparison of synaptic transmission and network activity between patient and control organoids would further test this hypothesis.
