The subjects for this study were extracted from two protocols where subgroups had received both alcohol challenges and filled out the SRE in close contiguity. The first group included 55 male offspring aged 18-to-29 from the Collaborative Study on the Genetics of Alcoholism (COGA) who had been recruited for alcohol challenges at the San Diego site (Schuckit et al., 1996). COGA is a six-center wide collaborative effort where each site recruited families of alcohol-dependent men who entered alcohol and drug treatment programs in the early-to-mid-1990’s. The original subjects were chosen based on meeting alcohol dependence criteria of the Third Revised Statistical Manual of Mental Disorders (DSM-III-R) (American Psychiatric Assn., 1987), and who fulfilled criteria for definite alcoholism as presented in the Feighner criteria (Feighner et al., 1972). Each center also recruited comparison subjects using a variety of methods including random mailings, drivers license records, as well as the random selection among participants in medical or dental clinics (Bucholz et al., 1994; Schuckit et al., 1996). All original probands, available first and second degree relatives including these offspring, and members of
