The importance of GABAA-Rs in different brain regions and behaviors has been reinforced in recent years, with recognition that GABAA-Rs come in many different flavors differing in subunit combination, resulting in subtypes that vary in physiology, pharmacology, and most importantly, in location. Both the circuitry and the subcellular location on different postsynaptic membranes and extrasynaptic membranes is important for GABAA-R control of neuronal excitability, circuit, and network activity.
