In summary, we have shown that a polymorphism in GABRA2 interacting with recent drinking history is associated with the acute adaptation to steady-state alcohol intoxication. The measure of adaptation included as components the subjective responses of intoxication, enjoyment, number of drinks, stimulation, relaxation, anxiety, and tiredness as achieved with intravenous administration. It is possible that for individuals who are homozygous for the C allele, heavy drinking leads to a more positive drinking experience, leading to a greater risk for developing an alcohol use disorder. Further analyses are warranted not only to replicate these findings, but also to evaluate their predictive value in anticipating problem drinking, and whether they can be extended to subjects of other ethnic background. If confirmed, these results will aid in understanding the complex mechanisms contributing alcohol dependence.
