The present findings establish a new context for interpretation of previous studies showing differences in frontal alpha band power and synchrony between subjects with MDD and normal controls [34]–[36], [38]. Studies have shown increases in synchronized frontal alpha activity and qEEG alpha power, although the lateralization has varied, with relatively greater alpha power reported both over left and right anterior regions [34], [36], [68]. It is possible that shifting power asymmetries previously reported [35] may reflect the effects of significantly increased functional connectivity in subjects with MDD. Recent results indicate that interhemispheric interactions are related to shifting lateralization on a moment-to-moment basis in MDD [69]. Future studies should examine the role of increased connectivity in modulating asymmetries in frontal power.
